首页> 外文OA文献 >High incidence of interleukin 10 mRNA but not interleukin 2 mRNA detected in human breast tumours.
【2h】

High incidence of interleukin 10 mRNA but not interleukin 2 mRNA detected in human breast tumours.

机译:在人乳腺肿瘤中检出白介素10 mRNA的发生率很高,但未检出白介素2 mRNA。

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务,本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文,但由于OA文献来源多样且变更频繁,仍可能出现获取不到、文献不完整或与标题不符等情况,如果获取不到我们将提供退款服务。请知悉。

摘要

Despite the presence of a lymphocytic infiltrate in solid cancers, the failure for tumour growth to be contained suggests an inadequate immune response to the tumour. Poor cytotoxicity exerted by tumour-infiltrating lymphocytes (TILs) against tumour cells in vitro, combined with continued tumour growth in vivo, suggests deficiencies in TIL function or numbers. Various theories have been postulated to explain how tumour cells may escape immunosurveillance and control. One of the many hypotheses is the failure of production of cytokines, which are necessary for T cells to mediate their function. Thus, the expression of cytokine mRNA in human breast tumour sections was investigated by reverse transcriptase polymerase chain reaction (RT-PCR) with cytokine-specific primers. A relatively consistent finding was detection of interleukin (IL) 10 mRNA among the tumours. No IL-2 and little IL-4 mRNA was detected in the tumours. IL-6 and IL-10 mRNA was detected in only one and two of the normal breast tissues respectively. IL-2, IL-4 and tumour necrosis factor (TNF)-alpha mRNA was not detected in any of the normal breast tissues. The reduced function of TILs may be related to IL-10, which has known inhibitory effects on T-cell activation.
机译:尽管在实体癌中存在淋巴细胞浸润,但无法遏制肿瘤生长表明对肿瘤的免疫反应不足。肿瘤浸润淋巴细胞(TIL)在体外对肿瘤细胞产生的不良细胞毒性,再加上体内肿瘤的持续生长,提示TIL功能或数量存在缺陷。已经提出了各种理论来解释肿瘤细胞如何逃避免疫监视和控制。许多假设之一是细胞因子产生失败,这是T细胞介导其功能所必需的。因此,用细胞因子特异性引物通过逆转录酶聚合酶链反应(RT-PCR)研究了人乳腺肿瘤切片中细胞因子mRNA的表达。相对一致的发现是在肿瘤之间检测了白介素(IL)10 mRNA。在肿瘤中未检测到IL-2,几乎未检测到IL-4 mRNA。仅在正常乳腺组织中的一种和两种中分别检测到IL-6和IL-10 mRNA。在任何正常的乳腺组织中均未检测到IL-2,IL-4和肿瘤坏死因子(TNF)-αmRNA。 TIL的功能降低可能与IL-10有关,后者对T细胞活化具有已知的抑制作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号